1 Co - infection of Leptomonas seymouri with Leishmania donovani in Indian Leishmaniasis 1 Running
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Co-infection of Leptomonas seymouri with Leishmania donovani in Indian Leishmaniasis 1 Running Title: Co-infection of Leptomonas seymouri with Leishmania donovani 2 3 Susmita Ghosh, Priyanka Banerjee, Avijit Sarkar, Sudipto Ganguly, Simanti Datta* 4 and Mitali Chatterjee* 5 6 Dept. of Pharmacology and Centre for Liver Research, School of Digestive and Liver 7 Diseases, Institute of Post Graduate Medical Education and Research, 244B, Acharya JC 8 Bose Road, Kolkata-700 020 9 10 *To whom correspondence should be addressed: 11 Dr. Mitali Chatterjee, MD PhD Dr. Simanti Datta, PhD 12 Dept. of Pharmacology, Centre for Liver Research, 13 Institute of PG Med Edn and Research, School of Digestive and Liver Diseases 14 244 B Acharya JC Bose Road, Institute of PG Med Edn and Research, 15 Kolkata 700 020, India 244 Acharya JC Bose Road, 16 Tel: 91 33 2223 4135 Kolkata 700 020, India 17 Fax: 91 33 2223 4135, Tel: 91 33 2223 5435 18 Email: [email protected] Fax: 91 33 2223 5435 19 E-mail: [email protected] 20 21 Copyright © 2012, American Society for Microbiology. All Rights Reserved. J. Clin. Microbiol. doi:10.1128/JCM.00966-12 JCM Accepts, published online ahead of print on 23 May 2012
منابع مشابه
Coinfection of Leptomonas seymouri and Leishmania donovani in Indian leishmaniasis.
Leishmania donovani is considered the causative organism of visceral leishmaniasis (VL) and post-kala-azar dermal leishmaniasis (PKDL). Testing of 4/29 DNA samples from VL and PKDL patients as well as 2/7 field isolates showed an aberrant internal transcribed spacer 1 (ITS1) restriction fragment length polymorphism (RFLP) pattern, which upon sequencing strongly matched Leptomonas seymouri, thus...
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The co-infection cases involving dixenous Leishmania spp. (mostly of the L. donovani complex) and presumably monoxenous trypanosomatids in immunocompromised mammalian hosts including humans are well documented. The main opportunistic parasite has been identified as Leptomonas seymouri of the sub-family Leishmaniinae. The molecular mechanisms allowing a parasite of insects to withstand elevated ...
متن کاملSOLiD™ Sequencing of Genomes of Clinical Isolates of Leishmania donovani from India Confirm Leptomonas Co-Infection and Raise Some Key Questions
BACKGROUND Known as 'neglected disease' because relatively little effort has been applied to finding cures, leishmaniasis kills more than 150,000 people every year and debilitates millions more. Visceral leishmaniasis (VL), also called Kala Azar (KA) or black fever in India, claims around 20,000 lives every year. Whole genome analysis presents an excellent means to identify new targets for drug...
متن کاملEvaluation of antigens for the serodiagnosis of kala-azar and oriental sores by means of the indirect immunofluorescence antibody test (IFAT).
Antigens and corresponding sera were collected from travellers with leishmaniasis returning to Germany from different endemic areas of the old world. The antigenicity of these Leishmania strains, which were maintained in Syrian hamsters, was compared by indirect immunofluorescence (IFAT). Antigenicity was demonstrated by antibody titres in 18 sera from 11 patients. The amastigotic stages of nin...
متن کاملLeptomonas seymouri and Crithidia fasciculata exoantigens can discriminate human cases of visceral leishmaniasis from American tegumentary leishmaniasis ones
Exoantigens (exo) from Leptomonas seymouri and Crithidia fasciculata were used in an enzyme linked immunosorbent assay (ELISA), showing 100% reactivity with sera from visceral leishmaniasis (VL) cases, and no reactivity with American tegumentary leishmaniasis (ATL) ones. Our results have indicated that these exoantigens can be applied in the discrimination of VL and ATL cases.
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